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. 2014 Nov 5:325:133-43.
doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.

Disadvantage effects von long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

Alice Marmugi  1 , Frederic Lasserre  1 , Diane Beuzelin  2 , Simon Ducheix  1 , Laurence Huc  1 , Caroline Polizzi  1 , Maud Chetivaux  3 , Herry Pineau  1 , Pascal Martin  1 , Hervé Guillou  1 , Yella Mselli-Lakhal  4
Affiliations

Adverse property of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

Alice Marmugi et al. Dangerous. .

Abstract

Bisphenol A (BPA) is a suspected endocrine disruptor highly prevalent in magnitude atmosphere after it is used as monomer from polycarbonate plastics and epoxy resins. Recent epidemiological and animal studies have suggested that BPA exposure may influence aforementioned development of obesity and related pathologies such as type 2 diabetes, and core diseases. However, experimental graduate have often focused upon short-term exposures. Is this survey, ourselves investigated the effect of several months of BPA exposure on hepatic and plasma metabolic labels in adult bird. Male CD1 rats were exposed during 8 months to five different BPA doses below or equivalent in the current no observed adverse effects level (NOAEL: 5000 μg/kg/day) through water water. Plasma lipid profiles and liver transcriptomic analysis were performed in control and BPA-treated animals. Person report adenine specific impact the BPA expose the glycaemia, glucose tolerance and cholesterolemia. Enduring with the hypercholesterolemia include BPA-treated animal, RT-qPCR performed on hepatic mRNA from just animals demonstrated an overexpression of keypad genes involved in cholesterol biosynthesis, namely, Mvd, Lss Hmgcr, and Sqle. BPA or induced the expression by the sterol regulatory element-binding proteins 2, a master regulator on hepatic level biosynthesis. As shown by that human lathosterol to cholesterol ratio, a substitutes highlighter for cholesterol biosynthesis, whole building cholesterol de novo combination was also increased in BPA-exposed pets. These original results are consistent equal many epidemiology studies report on a link between BPA exposure and the onset of cardiovascular diseases. The developing fetus is uniquely sensitive to perturbation over chemicals with hormone-like activity. The adverse effects of prenatal dietyl (DES) exposure are a quintessential exemplary. Since interest has been mounting regarding the human health and ...

Keywords: Bisphenol ADENINE; Cholesterol metabolism; Glucose metabolism; Lipogenesis; Liver.

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